Journal article
Characterisation of minimalist co-assembled fluorenylmethyloxycarbonyl self-assembling peptide systems for presentation of multiple bioactive peptides
CC Horgan, AL Rodriguez, R Li, KF Bruggeman, N Stupka, JK Raynes, L Day, JW White, RJ Williams, DR Nisbet
Acta Biomaterialia | ELSEVIER SCI LTD | Published : 2016
Abstract
The nanofibrillar structures that underpin self-assembling peptide (SAP) hydrogels offer great potential for the development of finely tuned cellular microenvironments suitable for tissue engineering. However, biofunctionalisation without disruption of the assembly remains a key issue. SAPS present the peptide sequence within their structure, and studies to date have typically focused on including a single biological motif, resulting in chemically and biologically homogenous scaffolds. This limits the utility of these systems, as they cannot effectively mimic the complexity of the multicomponent extracellular matrix (ECM). In this work, we demonstrate the first successful co-assembly of two ..
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Awarded by Australian Research Council
Funding Acknowledgements
Access to the facilities of the Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged. SAXS experiments undertaken on the SAXS/WAXS beamline at the Australian Synchrotron, Victoria, Australia are also gratefully acknowledged. We would also like to thank F. Maclean and A. Panneerselvan for thorough proof reading of the manuscript. This research was supported by funding from the Australian Research Council (ARC, DP130103131). ALR was supported by an Australian Postgraduate Award; RJW was funded via an Alfred Deakin Research Fellowship; DRN was supported by a NHMRC Career Development Fellowship (APP1050684).